Patrick Dempsey Pays Emotional Tribute to Grey’s Anatomy Co-Star Eric Dane

Actor Patrick Dempsey has shared a heartfelt tribute to his former Grey’s Anatomy co-star Eric Dane, remembering him as a joyful presence and a cherished friend following his death at age 53. Dane passed away after battling amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease.

Dempsey reflected on their final conversations, revealing that he had spoken with Dane just a week before his passing. He expressed deep sorrow for Dane’s children and family, noting that the actor spent his final days surrounded by loved ones.

“The Funniest Man”: Remembering His Energy and Humour

Dempsey described Dane as one of the funniest people he had worked with and recalled the lively energy he brought to the set. He reminisced about their first scene together, a moment that became memorable for fans and cemented their on-screen chemistry.

Beyond the humour, Dempsey spoke about the deep friendship they shared and the joy Dane brought to colleagues throughout his career.

Health Decline in Final Days

According to Dempsey, Dane’s condition worsened rapidly in his final weeks. He became bedridden, struggled with swallowing, and gradually lost his ability to speak as the disease progressed.

ALS affects nerve cells controlling voluntary muscles, leading to progressive paralysis. The condition remains incurable and is considered the most common form of motor neuron disease.

Advocate for ALS Awareness

After publicly revealing his diagnosis in 2025, Dane became a vocal advocate for ALS awareness and research. He spoke openly about the physical and emotional toll of the illness, using interviews and appearances to raise awareness and encourage support for ongoing research.

His honesty and courage resonated with fans and helped bring wider attention to the disease.

Career Highlights and Lasting Legacy

Eric Dane gained global recognition for his role as Dr. Mark “McSteamy” Sloan on Grey’s Anatomy, appearing from 2006 to 2012. He later reached a new generation of viewers through his role as Cal Jacobs in Euphoria.

One of his final performances carried poignant resonance, portraying a firefighter living with ALS in Brilliant Minds in 2025.

Tributes have poured in from across the entertainment industry, but Dempsey’s reflections on their laughter and friendship capture the warmth and humanity that defined Dane’s life.

Dane is remembered not only for his memorable performances but also for his courage, humour, and the compassion he inspired in others.